Mechanisms of ischemic kidney tolerance in young and senescence-accelerated rats exposed to ischemic preconditioning or calorie restrictionтезисы доклада
Дата последнего поиска статьи во внешних источниках: 30 декабря 2020 г.
Аннотация:Calorie restriction (CR) and ischemic preconditioning (IPC) are the most efficient approaches ameliorating the severity of different pathological conditions.We investigated the protective potential of long-term calorie
restriction and short ischemic preconditioning protocol in the model of acute kidney injury (AKI) in young Wistar and OXYS rats. In young rats, ischemic preconditioning, which consists of
4 cycles of ischemia and reperfusion alleviated kidney injury caused by 40-min ischemia. However, 6-month-old OXYS rats having signs of premature aging lost their ability to protect the
ischemic kidney by IPC. However, CR of OXYS rats led to a significant decrease in creatinine and blood urea nitrogen levels after kidney ischemia, indicating significant protection.