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The GAR domain integrates functions that are necessary for the proper localization of fibrillarin (FBL) inside eukaryotic cellsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 3 июня 2020 г.
- Авторы: Shubina MY, Arifulin EA, Sorokin DV, Sosina MA, Tikhomirova MA, Serebryakova MV, Smirnova T., Sokolov SS, Musinova YR, Sheval EV
- Журнал: PeerJ
- Том: 8
- Год издания: 2020
- Издательство: PeerJ
- Местоположение издательства: San Francisco
- Первая страница: e9029
- DOI: 10.7717/peerj.9029
- Аннотация: Fibrillarin (FBL) is an essential nucleolar protein that participates in pre-rRNA methylation and processing. The methyltransferase domain of FBL is an example of an extremely well-conserved protein domain in which the amino acid sequence was not substantially modified during the evolution from Archaea to Eukaryota. An additional N-terminal glycine–arginine-rich (GAR) domain is present in the FBL of eukaryotes. Here, we demonstrate that the GAR domain is involved in FBL functioning and integrates the functions of the nuclear localization signal and the nucleolar localization signal (NoLS). The methylation of the arginine residues in the GAR domain is necessary for nuclear import but decreases the efficiency of nucleolar retention via the NoLS. The presented data indicate that the GAR domain can be considered an evolutionary innovation that integrates several functional activities and thereby adapts FBL to the highly compartmentalized content of the eukaryotic cell.
- Добавил в систему: Шеваль Евгений Валерьевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | 2020_Shubina_PeerJ.pdf | 8,3 МБ | 29 апреля 2020 [sheval_e] |