Synthesis of the Tripeptides Tyr–Thr–Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samplesстатья
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Дата последнего поиска статьи во внешних источниках: 28 февраля 2020 г.
Аннотация:A procedure for the phosphorylation of the tripeptide Tyr−Thr−Lys with isopropyl methyl- or (deuteromethyl)phosphonochloridate is developed. The phosphorylated tripeptides are intended for use as reference standards in the analysis of blood samples of people suspected to have been exposed to acetylcholinesterase inhibitors. Conditions of chromatographic separation and purification of the synthesized compounds are determined and optimized, which ensures the preparation of high-purity phosphorylated tripeptides.