Nanocomposite Biomaterials Based on Hydroxyapatite Xerogel Glass

Musskaya, O.N.; Kulak, A.I.; Krut’ko, V.K.; Lesnikovich, L.A.; Ulasevich, S.A.

Авторы: Musskaya O.N., Kulak A.I., Krut’ko V.K., Lesnikovich L.A., Ulasevich S.A.
Журнал: Glass Physics and Chemistry
Том: 37
Номер: 5
Год издания: 2011
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 525
Последняя страница: 532
DOI: 10.1134/S1087659611050075
Аннотация: A hydroxyapatite xerogel with high adsorption–structural characteristics and nanometer-sized crystals has been synthesized using dehydration of a hydroxyapatite gel in air at temperatures of 20–40°C with dehydrating agents, cryogenic treatment (-18 and -196°C), lyophilic drying, and vacuum conductive-sorption drying. The following nanocomposite biomaterials based on the hydroxyapatite xerogel have been prepared and investigated: hardening hydroxyapatite cements, elastic “hydroxyapatite–fiber carrier (cellulose, carbon)” composites, and hydroxyapatite coatings on titanium substrates. It has been established that the hardening calcium phosphate cements based on a 4- to 17- wt% hydroxyapatite gel and a hydroxyapatite powder are haracterized by a hardening time in the interval from 1 min to 1 h and by a static strength up to 2.7 MPa. The hydroxyapatite content in the elastic composites varies from 4 to 540 mg/g depending on the type of fiber carriers and on the preparation conditions. In vitro and in vivo preclinical tests performed on rats have demonstrated that titanium implants with a biocoating based on the hydroxyapatite cement possess a high biocompatibility and a toxicological safety.
Добавил в систему: Крутько (Цубер) Валентина Константиновна

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