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Effects of the novel anticonvulsant levetiracetam on the content of monoamines and their main metabolites in the brain structures of rats of the Krushinskii-Molodkina strainстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Malikova L.A., Fedotova I.B., Narkevich V.B., Klodt P.M., Kudrin V.S., Poletaeva I.I., Raevskii K.S.
- Журнал: Neurochemical Journal
- Том: 2
- Номер: 4
- Год издания: 2008
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 289
- Последняя страница: 292
- DOI: 10.1134/S1819712408040090
- Аннотация: We have studied the effects of levetiracetam, a novel anticonvulsant drug, on the content of monoamines and their metabolites in the frontal cortex, hypothalamus, striatum, and medulla of rats of the Krushinskii-Molodkina strain using the HPLC technique with electrochemical detection. The anticonvulsive effect of intraperitoneal injection of levetiracetam (80 mg/kg) was accompanied by an increase in the content of dihydroxyphenylacetic and homovanillic acids and/or changes in the rate of dopamine turnover in all the structures studied. The parameters of the norepinephrine- and serotonergic systems remained unchanged. Keeping the data on the abnormalities in the dopaminergic system in epilepsy-prone Krushinskii-Molodkina rats in mind, it is possible to conclude that this system plays an important role in the mechanism of the anticonvulsant effect of levetiracetam. © MAIK Nauka 2008.
- Добавил в систему: Федотова Ирина Борисовна