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Postsynaptically different inhibitory postsynaptic currents in Cajal-Retzius cells in the developing neocortexстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 11 апреля 2019 г.
- Авторы: Dvorzhak A., Myakhar O., Kamkin A., Kirmse K., Kirischuk S.
- Журнал: NeuroReport
- Том: 19
- Номер: 12
- Год издания: 2008
- Издательство: Lippincott Williams & Wilkins Ltd.
- Местоположение издательства: United States
- Первая страница: 1213
- Последняя страница: 1216
- Аннотация: Fast and slowly rising inhibitory postsynaptic currents (IPSCs, IPSCF and IPSCS) in neocortical Cajal-Retzius cells are observed. In this study, zolpidem, a benzodiazepine agonist that specifically modulates gamma-aminobutyric acid type A receptors (GABAARs) containing gamma2 subunit, was used to characterize GABAARs mediating IPSCF and IPSCS. One-hundred-nanomolar zolpidem prolonged IPSCS, increased evoked IPSCS (eIPSCS) amplitude, and decreased paired-pulse ratio (PPR) of eIPSCS. Two micromolar zolpidem prolonged both IPSCF and IPSCS, increased miniature IPSCF and eIPSCF amplitudes, increased eIPSCS amplitude but not miniature IPSCS amplitude, decreased PPR of eIPSCS, but failed to affect PPR of eIPSCF. We conclude that IPSCF are mediated by alpha2/3-containing GABAARs, which are not saturated by synaptic GABA release, whereas IPSCS are mediated by alpha1-containing and alpha2/3-containing GABAARs, which are saturated by quantal GABA release.
- Добавил в систему: Дворжак Антон Юрьевич
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