Highly diastereoselective synthesis of chimeras of proline and glutamateстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:Azomethine ylides have been generated from aromatic aldimines of α-amino acid methyl esters under treatment with LiBr/Et3N and trapped with tert-butyl acrylate yielding racemic orthogonally protected cis-5-arylpyrrolidine-2,4-dicarboxylates regio- and stereo-selectively in high yields. Subsequent N-methylation and deprotection of 4-carboxylic group of cycloaddition products led to novel proline-glutamate cis-chimeras with substituents at 2 and 5 positions of pyrrolidine scaffold.