Furosemide and DIDS penetration into Langmuir films of stearic acid. the influence of low ionic strength and pHстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Авторы:
Tverdislov V.A. ,
Khomutov G.B. ,
Yakovenko S.A. ,
Youn H.D. ,
Bogdanova A.Y. ,
Bernhardt I.
Журнал:
Colloids and Surfaces B: Biointerfaces
Том:
5
Номер:
5
Год издания:
1995
Издательство:
Elsevier BV
Местоположение издательства:
Netherlands
Первая страница:
205
Последняя страница:
211
DOI:
10.1016/0927-7765(95)01216-1
Аннотация:
The interaction of two classical inhibitors of ion transport across biological membranes, 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid (DIDS) and furosemide, with stearic acid monolayers was investigated by measuring pressure-area isotherms of Langmuir films. Solutions of two different ionic strengths were chosen as water subphases to imitate flux media for investigation of the mechanism of residual ("leak") transport of monovalent cations (electrodiffusion) in native human red blood cells. As DIDS and furosemide are incorporated into the stearic acid monolayer, the conclusion can be made that both substances are able to modify the structure and the physicochemical properties of the membrane lipid bilayer. This in turn could cause changes in the ion permeability of biological membranes. © 1995 Elsevier Science B.V. All rights reserved.
Добавил в систему:
Хомутов Геннадий Борисович
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