Место издания:Nova Science Publishers, Inc New York
Первая страница:169
Последняя страница:186
Аннотация:The importance of cilia and flagella research has emerged in recent
years when it became clear that they play an important role in the normal
functioning of organs and tissues. “Ciliopathies” are complex multi-
system human disorders of cilia and flagella which affect almost all
organs, such as kidney, brain, eye, airways and skeleton. This disease
includes many syndromes, such as primary ciliary dyskinesia (PCD),
autosomal dominant and recessive polycystic kidney diseases, nephrono-phthisis, and some syndromes (for review, see Mitchison, Valente, 2017; Gonçalves, Pelletier, 2017; Reiter, Leroux, 2017). Despite the success of molecular biology in the study of genes whose mutations lead to the development of ciliopathies, the ultrastructural study of cilia and flagella remains, in some cases, an important diagnostic instrument. Here we
present a mini-review concerning ultrastructure of normal cilia and
flagella and some pathological conditions.
