ИСТИНА

The optical clearing agents (OCA) are widely used to increase the depth of light penetration into the studied biological tissues and organs and hence improve their visualization [1]. Recently, tartrazine, a common food dye, was successfully demonstrated as an effective OCA for skin imaging in living mouse in vivo [2]. This finding is highly promising for clinical translation, as tartrazine is pre-approved as a safe food additive by regulatory bodies like the U.S. FDA and the European Food Safety Authority (EFSA). Based on this, the present study aims to quantitatively evaluate the optical clearing efficacy of tartrazine on human finger phalanx tissue in vivo. Using OCT data, we directly compare the performance of tartrazine against other established OCAs to assess its potential for human applications.