ИСТИНА

Photocatalysis has been changing the modern organic synthesis. It provides new reactions pathways from known and makes possible to use mild conditions, particularly a room temperature. The last opens the road to high chemo-, regio- and even enantioselective radical processes. Merger of photoredox and transition metal catalysis allows to decrease the energy of the process significantly by conducting the reaction at room temperature. A combination of the photocatalyst and a transition metal catalyst in one molecule is a promising way to increase the efficiency of the photocatalytic system. In these processes the intramolecular transfer of energy or electrons between the photocatalyst and the metal complex determines the superior catalytic activity of bifunctional catalysts. Such hybrid systems afford to decrease the reaction time and the catalysts loadings. In this work using N,N-di(pyridin-2-yl)-1,10-phenanthrolin-4-amine as a bridging ligand we prepared the Ru(II) and Ir(III) complexes, possessing the additional chelating unit for transition metal coordination. These hybrid catalysts were studied in Ni/photoredox-catalyzed arylation of sodium arylsulfinates and amination of arylhalides under visible-light irradiation (455 nm, 12 W or 30 W). The advantage of binding photocatalyst and metal complex in one molecule, over mixed catalytic systems, is demonstrated in both investigated reactions. Using these catalysts we synthesized more than 50 cross-coupling products, including biologically active compounds and pharmaceuticals. The use of two irradiation techniques («in batch» and «in flow») will be also discussed.