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Robust and Scalable Stereoselective Synthesis of Trans-fused Octahydropyrrolo[2,3-c]azepin-4(5H)-ones Rigid Chemical Scaffolds as Research Tools for Allosteric Receptor Modulation Explorationдоклад на конференции
- Авторы: Lukyanenko Evgeny R., Belov Dmirty S., Andrea Altieri, Kurkin Alexander V.
- Международная Конференция : New Vistas in GPCR Research: the Dawn of an Exciting Drug Discovery Era? MedChem 2014
- Даты проведения конференции: 2014
- Тип доклада: Устный
- Докладчик: Kurkin Alexander V.
- Место проведения: Braine-L'Alleud, Belgium, Бельгия
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Аннотация доклада:
The cis- and trans-fused octahydropyrrolo[2,3-c]azepin-4(5H)-ones synthesis via aza-Cope-Mannich rearragement has been investigated. One of the most common aza-Cope-Mannich rearragements combines the cationic 2-aza-Cope rearrangement with a Mannich cyclization. This tandem reaction well fit for pyrrolidine compound array generations since is characterized by mild reaction conditions, diasteroselectivity, and a wide synthetic versatility. It provides easy access to acyl-substituted pyrrolidines, a structure commonly found in natural products such as alkaloids, and has been used in the synthesis of a number of them, notably strychnine and crinine
- Добавил в систему: Куркин Александр Витальевич