ИСТИНА

The ability of Nanoparticle Tracking Analysis (NTA) to discriminate between weakly and strongly scattering particles has been tested. Only partial discrimination is possible with standard implementation of NTA. Algorithm based on particle spot shape analysis to limit the upper and lower edges of detection volume has been proposed. These improvements open the possibility for the new type of specific labelling in NTA, scattering labelling of soft particles, i.e. weakly scattering biological particles, including exosomes, viruses and protein aggregates.