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The principle of 3R’s should be implemented and all the experiments should be designed to cause the least pain, suffering, distress or lasting harm to the animals used. All procedures on animals should be assigned a severity classification (mild, moderate, severe or non-recovery). The severity of the procedures should be classified prospectively and by the end of project the actual severity should be assigned The Severity Classification Allows for more careful planning of experiments implementing the least constraining procedures, anticipate methods for the alleviation of the animals’ suffering, keep the level of severity the lowest possible, Increase the reliability of experimental data Ensure the similarity in assessing the condition of animals in the course of experimental procedures Enables the integration of Institutions within and between countries in the formation of common modern standards for working with laboratory animals Facilitating the mutual acceptance of publications in the international journals Help to improve communication with the public by providing a more detailed picture of animal experimentation