ИСТИНА

DNA eukaryotic nuclei is compacted and organized by formaton of hierarchically organized DNA-protein complex termed as chromatin. Chromatin DNA is organized into nucleosomes – octamers of histone proteins wrapped by ~150 bp of DNA. Structure and dynamics of nucleosomes have been well-characterized during the last few decades, whilst higher levels of chromatin organization remain relatively understudied. Higher-order chromatin structure is known to play an important role in transcription and epigenetic regulation. Development of new chromatin models and imaging approaches may help broaden our understanding of these processes