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Silicon and iron composite has been synthesized by femto-second laser ablation of the target, prepared of silicon and α-iron silicide mixture, in acetone. Scanning Electron Microscopy showed that the composite consisted of spherical nanoparticles with diameter range from 20 to 250 nm. Raman spectroscopy revealed the presence of crystalline silicon in the composite. Synthesized composite demonstrated low transmittance, efficient photon conversion (~ 17.0 %) and excellent photostability. We think that the composite may be used as nanomaterial for photothermal treatment of cancer. [1] A. V. Kabashin, A Singh, M.T. Swihart, I.N. Zavestovskaya, P.N. Prasad, Laser-Processed Nanosilicon: A Multifunctional Nanomaterial for Energy and Healthcare, ACS Nano, vol. 13, pp. 9841–9867, 2019. [2] N. Fernandes, C.F. Rodrigues, A.F. Moreira, I.J. Correia, Overview of the application of inorganic nanomaterials in cancer photothermal therapy, Biomater. Sci., vol. 8, pp. 2990–3020, 2020. [3] N.V. Sharonova, E. V. Svirshchevskaya, A.A. Popov, N.V. Karpov, G.V. Tikhonovskiy, A.Y. Zakharkiv, S.V. Sizova, V.Y. Timoshenko, S.M. Klimentov, V.A. Oleinikov, Interaction of SiFe Nanoparticles with Epithelial and Lymphoid Cells, Russ. J. Bioorganic Chem., vol. 46, pp. 1198–1206, 2020.