ИСТИНА

The development of new intelligent drug delivery systems to overcome unwanted side effects and maximize the therapeutic effectiveness of chemotherapy for cancer diseases is one of the main tasks of modern medicine. Active research is being conducted to explore various nanosized drug carriers (nanocarriers) for these purposes. The use of porous silicon nanoparticles as the basis for nanocarriers is due to the unique properties of these solid-state nanomaterials, such as high biocompatibility [1] and complete biodegradability into non-toxic silicic acid [2]. The porous structure of the nanoparticles, with porosity values reaching up to 80% of their volume, provides a high drug-loading capacity for efficient drug delivery [3]. The simplicity of surface modification methods for the nanoparticles enables specific targeted delivery of various hydrophobic and hydrophilic drugs, radiopharmaceuticals, proteins, peptides, RNA, etc. into cells. The presence of efficient luminescence in porous silicon nanoparticles allows their utilization as contrast agents for bioimaging of cells and tissues [5]. The properties of porous silicon nanoparticles, acting as photosensitizers [6], sensitizers of high-frequency electromagnetic fields [7] and therapeutic ultrasound [8], provide them with therapeutic functions and the potential for stimuli-triggered drug release from the nanopores of nanocarriers.