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Binuclear coordination compounds of Cu (I), (II) on the basis of 2-thioxo-tetrahydro-4H-imidazole-4-one: a modification to stabilize Cu 1+ valence state in physiological fluids доклад на конференции
- Авторы: Guk D.A., Makarov M.M., Malinnikov V.M., Majouga A.G., Beloglazkina E.K., Zyk N.V., Krasnovskaya O.O.
- Международная Конференция : The Fourth International Scientific Conference «Advances in Synthesis and Complexing”
- Даты проведения конференции: 24 апреля - 28 июня 2017
- Дата доклада: 25 апреля 2017
- Тип доклада: Устный
- Докладчик: не указан
- Место проведения: Москва, Россия
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Аннотация доклада:
The use of cytotoxic drugs based on platinum has shown that coordination compounds, based on metals, can destroy the cancerous cells, disrupting the structure of DNA, and depriving them of their ability to divide. However, the platinum drugs have a high overall toxicity, and now search is on for anticancer therapeutic agents based on biogenic metals. In particular members of our laboratory have synthesized dinuclear mixed-valence complexes Cu (I, II) containing 2-substituted-5-Alkylthio arylmethylene-4-imidazolin-4-ones, which showed high cytotoxicity against many cell lines.
- Добавил в систему: Макаров Михаил Михайлович