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ULTRASOUND-ASSISTED DRUG RELEASE FROM BIODEGRADABLE POROUS SILICON NANOPARTICLESдоклад на конференции
- Авторы: SVIRIDOV A., TSURIKOVA U., MAKSUTOVA D., GONGALSKY M., EGOSHINA V., ANDREEV V.G., KUDRYAVTSEV A.A., OSMINKINA L.
- Международная Конференция : Porous Semiconductors Science and Technology 2022 Conference (PSST 2022, March 27th – April 1st 2022 Lido di Camaiore, Italy)
- Даты проведения конференции: 27 марта - 1 апреля 2022
- Дата доклада: 28 марта 2022
- Тип доклада: Стендовый
- Докладчик: не указан
- Место проведения: Lido di Camaiore, Италия
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Аннотация доклада:
The current study is devoted to both theoretical and experimental investigation of sonoactivation of drug-loaded mesoporous silicon nanoparticles (PSi NPs) with the MHz-range ultrasound irradiation (USI) of moderate intensity. The role of two fundamental effects acoustic cavitation and USI-induced heat deposition is taken into account. The experiments on USI-assisted doxorubicin (DOX) release in situ reveal an effective output of the drug from the PSi NPs even at low intensities. This effect is also confirmed by a significant inhibition of cancer cell proliferation in vitro.
- Добавил в систему: Осминкина Любовь Андреевна