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Skin Challenges 2018 will be held under the patronage of the International Microbiota Society (IMS) and the International Society of Antioxidants in Nutrition and Health (ISANH). Today, people live older thanks to new advances in medicine but they are becoming more demanding. They want to age in excellent health conditions and they want to look younger. That’s why the Anti-Ageing Medicine seeks to find effective ways to fight against ageing and skin ageing in particular by different actions: oral or topical cosmetics, plastic surgery, regenerative medicine with stem cells and many other actions. Ageing is an international issue that has social, economic and individual impacts. Preventing it and decreasing its side effects (all related pathologies) are major challenges for humanity. Thus the understanding of ageing and skin ageing mechanisms, related diseases, and recent ageing and skin-ageing delaying advances is a most for future populations. During Skin Challenges 2018, the Scientific Committee will allocate significant time to discuss the latest advances related to skin homeostasis and ageing. Our objective is to provide answers and to give a future vision and trends of how can the current research delay the side effects of ageing and skin ageing? The scientific committee will provide more time and space to present the recent innovations, biotechnology products and devices during the two days of conference. Among the hot topics which will be discussed in Porto: skin ageing mechanisms, mitochondria, Nrf2 modulation, gut and skin microbiota inter-talk, exposomes and others… The aims of Skin Challenges 2018 are to: Draft the state of the art in skin ageing Present the different mechanisms involved in homeostasis and skin aging but also to address the different tracks and pathways (signaling, transcription factors…) involved in this process Highlight the recent innovations in skin ageing and photo ageing Present the new notion of exposome and skin aging What are the internal and external factors that we can qualify as exposome? What is the response of the body and the skin barrier to these internal and external factors? What is the current state of knowledge about the interaction of distinct exposomal factors with each other and what is the resulting effect on skin aging? How to determine the influence of these exposomes on skin aging? Which kind of protective measures should be considered to limit cutaneous aging? Discuss the role of microbiota and skin microbiota What is the role of gut microbiota and skin microbiota on skin ageing? What is the importance of quality and diversity of microbiota on skin barrier? What are the factors (pre/probiotics, bacteria…) able to influence the skin microbiota ? Present the practical applications of algae uses in cosmetic industry Discussion: what is the strategic role of skin olfactory receptors and smell? How to explain the regeneration and cicatrisation by olfacory receptors activation? What is the impact of smell on skin ageing? Skin Challenges 2018 will gather major actors in the ageing and skin-ageing area and will target researchers and academic professors, R&D departments, clinicians, pharmaceutical companies, food supplement companies, cosmetics companies, marketing departments, investors, start ups and all other stakeholders in the skin ageing industry.