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The CCBB conference 2025 will take a uniquely broad approach to cartilage and bone biology, combining researchers from diverse disciplines including paleontology, developmental biology, evolutionary biology, anatomy, physiology, biomechanics, biomineralization, molecular genetics, regeneration and pathology. To build wider concepts in skeletal and dental biology, we will pay particular attention to work on less-studied tissue types, on evolutionary perspectives of skeletal diversity and on less traditional models for skeletal biology (e.g. cartilaginous and ray-finned fishes). Bringing together, in a beautiful location, excellent researchers from varied countries, fields and career stages, CCBB 2025 will foster collaboration, stimulate innovative research, and inspire development of novel approaches to enhance understanding of skeletons in the broadest sense.